| Identification | More | [Name]
Ropivacaine hydrochloride | [CAS]
132112-35-7 | [Synonyms]
ROPIVACAINE HCL
ROPIVACAINE HYDROCHLORIDE
ROPIVACAINE HYDROCHLORIDE MONOHYDRATE
ROPIVCACAINE HYDROCHLORIDE
S-ROPIVACAINE HCL
(S)-ROPIVACAINE HYDROCHLORIDE
(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate
(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine,monohydrochloride,monohydrate
(S)-Ropivaxaine hydrochloride
(S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
Ropivacaine hydrochloride
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate
LEA-103 | [EINECS(EC#)]
663-286-1 | [Molecular Formula]
C17H27ClN2O | [MDL Number]
MFCD02102164 | [Molecular Weight]
310.86 | [MOL File]
132112-35-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
267-269°C | [alpha ]
D20 -7.28° (c = 2 in water) | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble5mg/mL, clear | [form ]
powder | [color ]
white to off-white | [optical activity]
[α]/D -9 to -12, c = 1 in methanol | [Usage]
Anesthetic (local) | [InChIKey]
VSHFRHVKMYGBJL-CKUXDGONSA-N | [CAS DataBase Reference]
132112-35-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HS Code ]
2933399090 |
| Hazard Information | Back Directory | [Description]
(–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers.1 In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve.2 (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine (Item No. 16618).3 Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth. | [Chemical Properties]
White Solid | [Uses]
Anesthetic (local) | [Definition]
ChEBI: The monohydrate form of (S)-ropivacaine hydrochloride. | [General Description]
Ropivacaine has lidocaine-related structure with tertiary amine side chains.?It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom. | [Biochem/physiol Actions]
Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers. | [storage]
Store at -20°C |
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